Development and Evaluation of Topical Gel of Curcumin from Different Combination of Polymers Formulation & Evaluation of Herbal Gel
نویسندگان
چکیده
The present study was aimed to develop topical gel of Curcumin which enhances the bioavailability & permeation with the help of combination of polymers which will be useful in further drug delivery. Polymers plays major role in various characterization parameters of topical gel such as in vitro release and rheological properties. A stable, elegant formulation of curcumin gel was successfully prepared, overcoming problems of bioavailability and in comparison to other polymers (such as Carbapol & Sodium alginate) combination of Carbapol and HPMC presented higher % of drug diffusion, good rheological & texture properties. The release rate of gel was found to obey Peppas model.
منابع مشابه
Preclinical Evaluation of Silver-Curcumin Nano- gel : A complete assessment on a new topical antimicrobial product for burn
Nanosilver and nanocurcumin are popular nonmaterial with increasing public attention, but their synergistic therapeutic potentials in burns have never been considered. The present study aimed to provide a novel formulation from both nanomaterials (Ag – Curcumin NPs) and conduct their preclinical evaluation for burn healing. After evaluation of particle size, loading efficiency, release profile ...
متن کاملPreparation and physicochemical evaluation of topical formulations of purified curcuminoids from Curcuma longa rhizome
Background and objectives: The purpose of this study was optimization of semisolid topical formulation from ethanol extract of turmeric and evaluation of rheological characterization and investigation of physicochemical control tests. Methods: The ethanolic extract was prepared with Soxhlet method and the compounds were isolated with silica gel column chromatog...
متن کاملFormulation and Evaluation of A Novel Herbal Gel Of Stevia Extract
Background: The aim of this study was to formulate and evaluate the noble herbal moisturise gel containing Stevia extract. Methods: The cosmetic gel formulation was designed by using aqueous extract of Stevia rebaudiana leaves in varied concentrations (2.5% and 5.0%) and evaluated using physiological measurements in comparision with a control placebo gel. The initial physicochemical parameters ...
متن کاملFormulation and evaluation of curcumin gel for topical application.
The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin through the excised rat epidermis from 2% w/w CRB and HPC gel system was investi...
متن کاملDevelopment and In-vitro Evaluation of a Contraceptive Vagino-Adhesive Propranolol Hydrochloride Gel
The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...
متن کامل